Bone homeostasis
نویسندگان
چکیده
منابع مشابه
PPARγ in bone homeostasis.
The nuclear receptor peroxisome proliferator-activated receptor (PPAR)γ is a crucial cellular and metabolic switch that regulates many physiologic and disease processes. Emerging evidence reveals that PPARγ is also a key modulator of skeletal remodeling. Long-term use of rosiglitazone, a synthetic PPARγ agonist and a drug to treat insulin resistance, increases fracture rates among patients with...
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1 To whom correspondence should be addressed: The Harry B. & Aileen B. Gordon Diabetes Research Center, 1102 Bates, Suite 550, MC 3-2353, Houston, TX 77030. Tel: 832-8243764; FAX: 832-825-3766. E-mail: [email protected] 2 Current address: Department of Physiology & Biophysics, University of Arkansas for Medical Sciences, Little Rock, AR 72205 3 The abbreviations used are: AR, aldose reductase...
متن کاملBidirectional ephrinB2-EphB4 signaling controls bone homeostasis.
Bone homeostasis requires a delicate balance between the activities of bone-resorbing osteoclasts and bone-forming osteoblasts. Various molecules coordinate osteoclast function with that of osteoblasts; however, molecules that mediate osteoclast-osteoblast interactions by simultaneous signal transduction in both cell types have not yet been identified. Here we show that osteoclasts express the ...
متن کاملOsteocytes link bone maintenance to blood homeostasis.
O steocytes are the most abundant cell type in the bone, comprising more than 90% of all cells within the bone matrix or on bone surfaces. Osteocytes are derived from osteoblasts and are entombed in the bone matrix during bone deposition. Osteocytes were originally thought to be rather inert cells whose function was limited to maintaining bone matrix locally. However, osteocytes are connected t...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.23.13361